Diabetic kidney disease (DKD) remains one of the most serious complications of diabetes, demanding early and comprehensive intervention strategies. Advances in pharmacotherapy—such as SGLT2 inhibitors and GLP-1 receptor agonists—have shown promise in slowing renal decline and reducing cardiovascular risk. Early screening for albuminuria, blood pressure management, and tight glycemic control are key to preserving kidney function. Additionally, lifestyle modifications, including dietary adjustments and physical activity, play a crucial role in long-term renal protection. A multidisciplinary approach integrating endocrinology, nephrology, and patient education is essential to improve outcomes and quality of life for diabetic patients at risk of kidney disease.